Selective targeting of melanoma by PEG-masked protein-based multifunctional nanoparticles.

ABSTRACT:

Background

Nanoparticle-based systems are promising for the development of imaging and therapeutic agents. The main advantage of nanoparticles over traditional systems lies in the possibility of loading multiple functionalities onto a single molecule, which are useful for therapeutic and/or diagnostic purposes. These functionalities include targeting moieties which are able to recognize receptors overexpressed by specific cells and tissues. However, targeted delivery of nanoparticles requires an accurate system design. We present here a rationally designed, genetically engineered, and chemically modified protein-based nanoplatform for cell/tissue-specific targeting.

Methods

Our nanoparticle constructs were based on the heavy chain of the human protein ferritin (HFt), a highl

SUBMITTER: Vannucci L 

PROVIDER: S-EPMC3356193 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature