A panel of serum microRNAs as specific biomarkers for diagnosis of compound- and herb-induced liver injury in rats.

ABSTRACT:

Background

Drug-induced liver injury (DILI) has been a public, economic and pharmaceutical issue for many years. Enormous effort has been made for discovering and developing novel biomarkers for diagnosing and monitoring both clinical and preclinical DILI at an early stage, though progress has been relatively slow. Additionally, herb-induced liver injury is an emerging cause of liver disease because herbal medicines are increasingly being used worldwide. Recently, circulating microRNAs (miRNAs) have shown potential to serve as novel, minimally invasive biomarkers to diagnose and monitor human cancers and other diseases at early stages.

Methodology/principal findings

In order to identify candidate miRNAs as diagnostic biomarkers for DILI, miRNA expression profiles of serum an

SUBMITTER: Su YW 

PROVIDER: S-EPMC3356255 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature