Topological domains in mammalian genomes identified by analysis of chromatin interactions.

ABSTRACT: The spatial organization of the genome is intimately linked to its biological function, yet our understanding of higher order genomic structure is coarse, fragmented and incomplete. In the nucleus of eukaryotic cells, interphase chromosomes occupy distinct chromosome territories, and numerous models have been proposed for how chromosomes fold within chromosome territories. These models, however, provide only few mechanistic details about the relationship between higher order chromatin structure and genome function. Recent advances in genomic technologies have led to rapid advances in the study of three-dimensional genome organization. In particular, Hi-C has been introduced as a method for identifying higher order chromatin interactions genome wide. Here we investigate the three-dimensiona

SUBMITTER: Dixon JR 

PROVIDER: S-EPMC3356448 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature