Identifying sources of variation and the flow of information in biochemical networks.

ABSTRACT: To understand how cells control and exploit biochemical fluctuations, we must identify the sources of stochasticity, quantify their effects, and distinguish informative variation from confounding "noise." We present an analysis that allows fluctuations of biochemical networks to be decomposed into multiple components, gives conditions for the design of experimental reporters to measure all components, and provides a technique to predict the magnitude of these components from models. Further, we identify a particular component of variation that can be used to quantify the efficacy of information flow through a biochemical network. By applying our approach to osmosensing in yeast, we can predict the probability of the different osmotic conditions experienced by wild-type yeast and show that

SUBMITTER: Bowsher CG 

PROVIDER: S-EPMC3356633 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature