Orthodenticle and Kruppel homolog 1 regulate Drosophila photoreceptor maturation.

ABSTRACT: Neurons present a wide variety of morphologies that are associated with their specialized functions. However, to date very few pathways and factors regulating neuronal maturation, including morphogenesis, have been identified. To address this issue we make use here of the genetically amenable developing fly photoreceptor (PR). Whereas this sensory neuron is specified early during retinal development, its maturation spans several days. During this time, this neuron acquires specialized membrane domains while undergoing extensive polarity remodeling. In this study, we identify a pathway in which the conserved homeobox protein Orthodenticle (Otd) acts together with the ecdysone receptor (EcR) to directly repress the expression of the transcription factor (TF) Kruppel homolog 1 (Kr-h1). We dem

SUBMITTER: Fichelson P 

PROVIDER: S-EPMC3356647 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature