Human aldehyde dehydrogenase genes: alternatively spliced transcriptional variants and their suggested nomenclature.

ABSTRACT:

Objective

The human aldehyde dehydrogenase (ALDH) gene superfamily consists of 19 genes encoding enzymes critical for NAD(P)-dependent oxidation of endogenous and exogenous aldehydes, including drugs and environmental toxicants. Mutations in ALDH genes are the molecular basis of several disease states (e.g. Sjögren-Larsson syndrome, pyridoxine-dependent seizures, and type II hyperprolinemia) and may contribute to the etiology of complex diseases such as cancer and Alzheimer's disease. The aim of this nomenclature update was to identify splice transcriptional variants principally for the human ALDH genes.

Methods

Data-mining methods were used to retrieve all human ALDH sequences. Alternatively spliced transcriptional variants were determined based on (i) criteria for sequence

SUBMITTER: Black WJ 

PROVIDER: S-EPMC3356695 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature