QTL detection power of multi-parental RIL populations in Arabidopsis thaliana.

ABSTRACT: A major goal of today's biology is to understand the genetic basis of quantitative traits. This can be achieved by statistical methods that evaluate the association between molecular marker variation and phenotypic variation in different types of mapping populations. The objective of this work was to evaluate the statistical power of quantitative trait loci (QTL) detection of various multi-parental mating designs, as well as to assess the reasons for the observed differences. Our study was based on an empirical data of 20 Arabidopsis thaliana accessions, which have been selected to capture the maximum genetic diversity. The examined mating designs differed strongly with respect to the statistical power to detect QTL. We observed the highest power to detect QTL for the diallel cross with ra

SUBMITTER: Klasen JR 

PROVIDER: S-EPMC3356812 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature