A comprehensive genetic association study of Alzheimer disease in African Americans.

ABSTRACT:

Objectives

To evaluate the association of genetic variation with late-onset Alzheimer disease (AD) in African Americans, including genes implicated in recent genome-wide association studies of whites.

Design

We analyzed a genome-wide set of 2.5 million imputed markers to evaluate the genetic basis of AD in an African American population.

Subjects

Five hundred thirteen well-characterized African American AD cases and 496 cognitively normal African American control subjects.

Setting

Data were collected from multiple sites as part of the Multi-Institutional Research on Alzheimer Genetic Epidemiology (MIRAGE) Study and the Henry Ford Health System as part of the Genetic and Environmental Risk Factors for Alzheimer Disease Among African Americans (GenerAAtions) Stud

SUBMITTER: Logue MW 

PROVIDER: S-EPMC3356921 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature