Genetic polymorphisms and obesity influence estradiol decline during the menopause.

ABSTRACT:

Objectives

Obesity and genetic variation in aromatase and type 1 17-β hydroxysteroid dehydrogenase (HSD) could influence the E2 trajectory of decline during the menopause transition.

Design and participants

E2 trajectories during the menopause transition (phenotype) were identified using 5934 data points acquired annually from 681 women in Study of Women's Health across the Nation (SWAN), a multiethnic study of the mid-life. E2 trajectories were related to CYP19 and type I 17-βHSD single-nucleotide polymorphisms (SNPs) and obesity.

Results

(log) E2 trajectories began to decline precipitously 2 years before the final menstrual period (FMP). The trajectory of the (log) E2 decline varied with genotypes and obesity. (log) E2 rates of decline were greater in nonobese women

SUBMITTER: Sowers MR 

PROVIDER: S-EPMC3357071 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature