Chemoenzymatic synthesis of 1-deaza-pyridoxal 5'-phosphate.

ABSTRACT: The first synthesis of 1-deaza-pyridoxal 5'-phosphate (2-formyl-3-hydroxy-4-methylbenzyl phosphate) is described. The chemoenzymatic approach described here is a reliable route to this important isosteric pyridoxal phosphate analogue. This work enables elucidation of the role of the pyridine nitrogen in pyridoxal 5'-phosphate dependent enzymes.

SUBMITTER: Griswold WR 

PROVIDER: S-EPMC3357107 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature