Evaluation of allele-specific somatic changes of genome-wide association study susceptibility alleles in human colorectal cancers.

ABSTRACT:

Background

Tumors frequently exhibit loss of tumor suppressor genes or allelic gains of activated oncogenes. A significant proportion of cancer susceptibility loci in the mouse show somatic losses or gains consistent with the presence of a tumor susceptibility or resistance allele. Thus, allele-specific somatic gains or losses at loci may demarcate the presence of resistance or susceptibility alleles. The goal of this study was to determine if previously mapped susceptibility loci for colorectal cancer show evidence of allele-specific somatic events in colon tumors.

Methods

We performed quantitative genotyping of 16 single nucleotide polymorphisms (SNPs) showing statistically significant association with colorectal cancer in published genome-wide association studies (GWAS).

SUBMITTER: Gerber MM 

PROVIDER: S-EPMC3357346 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature