Incidence, clinical predictors, genomics, and outcome of acute kidney injury among trauma patients.

ABSTRACT:

Objective

To determine clinical and genomic characteristics and in-hospital mortality risk associated with acute kidney injury (AKI) in the multicenter prospective cohort of patients with blunt trauma.

Summary background data

Less severe stages of AKI characterized by small changes in serum creatinine (sCr) are inadequately studied among trauma patients.

Methods

We performed a secondary analysis of the "Inflammation and the Host Response to Injury" (Glue Grant) database to include adult blunt trauma patients without history of kidney disease. AKI was defined by the Risk, Injury, Failure, Loss, and End-stage Kidney (RIFLE) classification, which requires a 50% increase in sCr and stratifies patients into following 3 severity stages: risk, injury, and failure. Associatio

SUBMITTER: Bihorac A 

PROVIDER: S-EPMC3357629 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature