Frequent occurrence of mitochondrial DNA mutations in Barrett's metaplasia without the presence of dysplasia.

ABSTRACT:

Background

Barrett's esophagus (BE) is one of the most common premalignant lesions and can progress to esophageal adenocarcinoma (EA). The numerous molecular events may play a role in the neoplastic transformation of Barrett's mucosa such as the change of DNA ploidy, p53 mutation and alteration of adhesion molecules. However, the molecular mechanism of the progression of BE to EA remains unclear and most studies of mitochondrial DNA (mtDNA) mutations in BE have performed on BE with the presence of dysplasia.

Methods/findings

Thus, the current study is to investigate new molecular events (Barrett's esophageal tissue-specific-mtDNA alterations/instabilities) in mitochondrial genome and causative factors for their alterations using the corresponding adjacent normal mucosal tiss

SUBMITTER: Lee S 

PROVIDER: S-EPMC3358277 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature