Mesenchymal stem cells enhance survival and bacterial clearance in murine Escherichia coli pneumonia.

ABSTRACT:

Rationale

Bacterial pneumonia is the most common infectious cause of death worldwide and treatment is increasingly hampered by antibiotic resistance. Mesenchymal stem cells (MSCs) have been demonstrated to provide protection against acute inflammatory lung injury; however, their potential therapeutic role in the setting of bacterial pneumonia has not been well studied.

Objective

This study focused on testing the therapeutic and mechanistic effects of MSCs in a mouse model of Gram-negative pneumonia.

Methods and results

Syngeneic MSCs from wild-type mice were isolated and administered via the intratracheal route to mice 4 h after the mice were infected with Escherichia coli. 3T3 fibroblasts and phosphate-buffered saline (PBS) were used as controls for all in vivo exper

SUBMITTER: Gupta N 

PROVIDER: S-EPMC3358432 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature