Ontology highlight
ABSTRACT:
SUBMITTER: Chen W
PROVIDER: S-EPMC3358529 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Chen Weiqiang W Villa-Diaz Luis G LG Sun Yubing Y Weng Shinuo S Kim Jin Koo JK Lam Raymond H W RH Han Lin L Fan Rong R Krebsbach Paul H PH Fu Jianping J
ACS nano 20120416 5
Human embryonic stem cells (hESCs) have great potentials for future cell-based therapeutics. However, their mechanosensitivity to biophysical signals from the cellular microenvironment is not well characterized. Here we introduced an effective microfabrication strategy for accurate control and patterning of nanoroughness on glass surfaces. Our results demonstrated that nanotopography could provide a potent regulatory signal over different hESC behaviors, including cell morphology, adhesion, prol ...[more]