Appetite regulation genes are associated with body mass index in black South African adolescents: a genetic association study.

ABSTRACT:

Background

Obesity is a complex trait with both environmental and genetic contributors. Genome-wide association studies have identified several variants that are robustly associated with obesity and body mass index (BMI), many of which are found within genes involved in appetite regulation. Currently, genetic association data for obesity are lacking in Africans-a single genome-wide association study and a few replication studies have been published in West Africa, but none have been performed in a South African population.

Objective

To assess the association of candidate loci with BMI in black South Africans. The authors focused on single nucleotide polymorphisms (SNPs) in the FTO, LEP, LEPR, MC4R, NPY2R and POMC genes.

Design

A genetic association study.

Participa

SUBMITTER: Lombard Z 

PROVIDER: S-EPMC3358621 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature