Evidence of IQ-modulated association between ZNF804A gene polymorphism and cognitive function in schizophrenia patients.

ABSTRACT: ZNF804A gene polymorphism rs1344706 has been suggested as the most compelling case of a candidate gene for schizophrenia by a genome-wide association study and several replication studies. The current study of 570 schizophrenia patients and 448 controls again found significantly different genotype frequencies of rs1344706 between patients and controls. More important, we found that this association was modulated by IQ, with a stronger association among individuals with relatively high IQ, which replicated results of Walters et al, 2010. We further examined whether this IQ-modulated association also existed between the SNP and the intermediate phenotypes (working memory and executive functions) of schizophrenia. Data were available from an N-back task (366 patients and 414 controls) and the

SUBMITTER: Chen M 

PROVIDER: S-EPMC3358743 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature