Dialysate flow rate and delivered Kt/Vurea for dialyzers with enhanced dialysate flow distribution.

ABSTRACT:

Background and objectives

Previous in vitro and clinical studies showed that the urea mass transfer-area coefficient (K(o)A) increased with increasing dialysate flow rate. This observation led to increased dialysate flow rates in an attempt to maximize the delivered dose of dialysis (Kt/V(urea)). Recently, we showed that urea K(o)A was independent of dialysate flow rate in the range 500 to 800 ml/min for dialyzers incorporating features to enhance dialysate flow distribution, suggesting that increasing the dialysate flow rate with such dialyzers would not significantly increase delivered Kt/V(urea).

Design, setting, participants, & measurements

We performed a multi-center randomized clinical trial to compare delivered Kt/V(urea) at dialysate flow rates of 600 and 800 ml/min

SUBMITTER: Ward RA 

PROVIDER: S-EPMC3358998 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature