Fibronectin matrix-mediated cohesion suppresses invasion of prostate cancer cells.

ABSTRACT:

Background

Invasion is an important early step in the metastatic cascade and is the primary cause of death of prostate cancer patients. In order to invade, cells must detach from the primary tumor. Cell-cell and cell-ECM interactions are important regulators of cohesion--a property previously demonstrated to mediate cell detachment and invasion. The studies reported here propose a novel role for α5β1 integrin--the principle mediator of fibronectin matrix assembly (FNMA)--as an invasion suppressor of prostate cancer cells.

Methods

Using a combination of biophysical and cell biological methods, and well-characterized prostate cancer cell lines of varying invasiveness, we explore the relationship between cohesion, invasiveness, and FNMA.

Results

We show that cohesion is

SUBMITTER: Jia D 

PROVIDER: S-EPMC3359283 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature