Primary progressive aphasia: a tale of two syndromes and the rest.

ABSTRACT:

Objective

Primary progressive aphasia (PPA) has been proposed to comprise 3 discrete clinical subtypes: semantic, agrammatic/nonfluent, and logopenic. Recent consensus recommendations suggest a diagnostic framework based primarily on clinical and neuropsychological findings to classify these variants. Our objective was to evaluate the extent to which patients with PPA would conform to the proposed tripartite system and whether the clustering pattern of elements of the linguistic profile suggests discrete clinical syndromes.

Methods

A total of 46 patients with PPA were prospectively recruited to the Cambridge Longitudinal Study of PPA. Sufficient data were collected to assess all consensus-proposed diagnostic domains. By comparing patients' performances against those of 30 ag

SUBMITTER: Sajjadi SA 

PROVIDER: S-EPMC3359509 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature