White matter imaging contributes to the multimodal diagnosis of frontotemporal lobar degeneration.

ABSTRACT:

Objective

To evaluate the distribution of white matter (WM) disease in frontotemporal lobar degeneration (FTLD) and Alzheimer disease (AD) and to evaluate the relative usefulness of WM and gray matter (GM) for distinguishing these conditions in vivo.

Methods

Patients were classified as having FTLD (n = 50) or AD (n = 42) using autopsy-validated CSF values of total-tau:β-amyloid (t-tau:Aβ(1-42)) ratios. Patients underwent WM diffusion tensor imaging (DTI) and volumetric MRI of GM. We employed tract-specific analyses of WM fractional anisotropy (FA) and whole-brain GM density analyses. Individual patient classification was performed using receiver operator characteristic (ROC) curves with FA, GM, and a combination of the 2 modalities.

Results

Regional FA and GM were sig

SUBMITTER: McMillan CT 

PROVIDER: S-EPMC3359585 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature