Impact of aging on pulmonary responses to acute ozone exposure in mice: role of TNFR1.

ABSTRACT:

Context

Chamber studies in adult humans indicate reduced responses to acute ozone with increasing age. Age-related changes in TNFα have been observed. TNFα induced inflammation is predominantly mediated through TNFR1.

Objective

To examine the impact of aging on inflammatory responses to acute ozone exposure in mice and determine the role of TNFR1 in age-related differences.

Materials and methods

Wildtype and TNFR1 deficient (TNFR1(-/-)) mice aged 7 or 39 weeks were exposed to ozone (2 ppm for 3 h). Four hours after exposure, bronchoalveolar lavage (BAL) was performed and BAL cells, cytokines, chemokines, and protein were examined.

Results

Ozone-induced increases in BAL neutrophils and in neutrophil chemotactic factors were lower in 39- versus 7-week-old wildtyp

SUBMITTER: Shore SA 

PROVIDER: S-EPMC3359651 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature