Enantioselective total synthesis of (+)-amabiline.

ABSTRACT: The first total synthesis of (+)-amabiline, an unsaturated pyrrolizidine alkaloid from Cynoglossum amabile, is reported. This convergent, enantioselective synthesis proceeds in 15 steps (10-step longest linear sequence) in 6.2% overall yield and features novel methodology to construct the unsaturated pyrrolizidine or (-)-supinidine core.

SUBMITTER: Senter TJ 

PROVIDER: S-EPMC3359844 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature