Emergence of distinct multiarmed immunoregulatory antigen-presenting cells during persistent viral infection.

ABSTRACT: During persistent viral infection, adaptive immune responses are suppressed by immunoregulatory factors, contributing to viral persistence. Although this suppression is mediated by inhibitory factors, the mechanisms by which virus-specific T cells encounter and integrate immunoregulatory signals during persistent infection are unclear. We show that a distinct population of IL-10-expressing immunoregulatory antigen-presenting cells (APCs) is amplified during chronic versus acute lymphocytic choriomeningitis virus (LCMV) infection and suppresses T cell responses. Although acute LCMV infection induces the expansion of immunoregulatory APCs, they subsequently decline. However, during persistent LCMV infection, immunoregulatory APCs are amplified and parallel the viral replication kinetics. Fur

SUBMITTER: Wilson EB 

PROVIDER: S-EPMC3359873 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature