Conflicting physiological and genomic cardiopulmonary effects of recruitment maneuvers in murine acute lung injury.

ABSTRACT: Low tidal volume ventilation, although promoting atelectasis, is a protective strategy against ventilator-induced lung injury. Deep inflation (DI) recruitment maneuvers restore lung volumes, but potentially compromise lung parenchymal and vascular function via repetitive overdistention. Our objective was to examine cardiopulmonary physiological and transcriptional consequences of recruitment maneuvers. C57/BL6 mice challenged with either PBS or LPS via aspiration were placed on mechanical ventilation (5 h) using low tidal volume inflation (TI; 8 μl/g) alone or in combination with intermittent DIs (0.75 ml twice/min). Lung mechanics during TI ventilation significantly deteriorated, as assessed by forced oscillation technique and pressure-volume curves. DI mitigated the TI-induced alteration

SUBMITTER: Mekontso Dessap A 

PROVIDER: S-EPMC3359949 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature