Inhibition of Pim1 kinase activation attenuates allergen-induced airway hyperresponsiveness and inflammation.

ABSTRACT: Pim kinases are a family of serine/threonine kinases whose activity can be induced by cytokines involved in allergy and asthma. These kinases play a role in cell survival and proliferation, but have not been examined, to the best of our knowledge, in the development of allergic disease. This study sought to determine the role of Pim1 kinase in the development of allergic airway responses. Mice were sensitized and challenged with antigen (primary challenge), or were sensitized, challenged, and rechallenged with allergen in a secondary model. To assess the role of Pim1 kinase, a small molecule inhibitor was administered orally after sensitization and during the challenge phase. Airway responsiveness to inhaled methacholine, airway and lung inflammation, cell composition, and cytokine concent

SUBMITTER: Shin YS 

PROVIDER: S-EPMC3359953 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature