Perivascular expression and potent vasoconstrictor effect of dynorphin A in cerebral arteries.

ABSTRACT:

Background

Numerous literary data indicate that dynorphin A (DYN-A) has a significant impact on cerebral circulation, especially under pathophysiological conditions, but its potential direct influence on the tone of cerebral vessels is obscure. The aim of the present study was threefold: 1) to clarify if DYN-A is present in cerebral vessels, 2) to determine if it exerts any direct effect on cerebrovascular tone, and if so, 3) to analyze the role of κ-opiate receptors in mediating the effect.

Methodology/principal findings

Immunohistochemical analysis revealed the expression of DYN-A in perivascular nerves of rat pial arteries as well as in both rat and human intraparenchymal vessels of the cerebral cortex. In isolated rat basilar and middle cerebral arteries (BAs and MCAs) D

SUBMITTER: Ruisanchez E 

PROVIDER: S-EPMC3360594 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature