Meta-analysis of the association between transforming growth factor-beta polymorphisms and complications of coronary heart disease.

ABSTRACT:

Objective

To investigate the association between common transforming growth factor beta (TGF-β) single nucleotide polymorphisms (SNP) and significant complications of coronary heart disease (CHD).

Method

We performed a meta-analysis of published case-control studies assessing the association of TGF-β SNPs with a range of CHD complications. A random effects model was used to calculate odds ratios and confidence intervals. Analyses were conducted for additive, dominant and recessive modes of inheritance.

Results

Six studies involving 5535 cases and 2970 controls examining the association of common SNPs in TGF-β1 with CHD were identified. Applying a dominant model of inheritance, three TGF-β1 SNPs were significantly associated with CHD complications: The T alleles of rs1

SUBMITTER: Morris DR 

PROVIDER: S-EPMC3360665 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature