PepMapper: a collaborative web tool for mapping epitopes from affinity-selected peptides.

ABSTRACT: Epitope mapping from affinity-selected peptides has become popular in epitope prediction, and correspondingly many Web-based tools have been developed in recent years. However, the performance of these tools varies in different circumstances. To address this problem, we employed an ensemble approach to incorporate two popular Web tools, MimoPro and Pep-3D-Search, together for taking advantages offered by both methods so as to give users more options for their specific purposes of epitope-peptide mapping. The combined operation of Union finds as many associated peptides as possible from both methods, which increases sensitivity in finding potential epitopic regions on a given antigen surface. The combined operation of Intersection achieves to some extent the mutual verification by the two m

SUBMITTER: Chen W 

PROVIDER: S-EPMC3360666 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature