Synthesis of the tetrasaccharide motif and its structural analog corresponding to the lipopolysaccharide of Escherichia coli O75.

ABSTRACT:

Background

Extraintestinal pathogenic E. coli are mostly responsible for a diverse spectrum of invasive human and animal infections leading to the urinary tract infections. Bacterial lipopolysaccharides are responsible for their pathogenicity and their interactions with host immune responses. In spite of several breakthroughs in the development of therapeutics to combat urinary tract infections and related diseases, the emergence of multidrug-resistant bacterial strains is a serious concern. Lipopolysaccharides are attractive targets for the development of long-term therapeutic agents to eradicate the infections. Since the natural sources cannot provide the required amount of oligosaccharides, development of chemical synthetic strategies for their synthesis is relevant to gain acce

SUBMITTER: Sau A 

PROVIDER: S-EPMC3360696 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature