Influence of prenatal arsenic exposure and newborn sex on global methylation of cord blood DNA.

ABSTRACT:

Background

An emerging body of evidence indicates that early-life arsenic (As) exposure may influence the trajectory of health outcomes later in life. However, the mechanisms underlying these observations are unknown.

Objective

The objective of this study was to investigate the influence of prenatal As exposure on global methylation of cord blood DNA in a study of mother/newborn pairs in Matlab, Bangladesh.

Design

Maternal and cord blood DNA were available from a convenience sample of 101 mother/newborn pairs. Measures of As exposure included maternal urinary As (uAs), maternal blood As (mbAs) and cord blood As (cbAs). Several measures of global DNA methylation were assessed, including the [3H]-methyl-incorporation assay and three Pyrosequencing assays: Alu, LINE-1 an

SUBMITTER: Pilsner JR 

PROVIDER: S-EPMC3360698 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature