Multiple SNPs in intron 41 of thyroglobulin gene are associated with autoimmune thyroid disease in the Japanese population.

ABSTRACT:

Background

The etiology of the autoimmune thyroid diseases (AITDs), Graves' disease (GD) and Hashimoto's thyroiditis (HT), is largely unknown. However, genetic susceptibility is believed to play a major role. Two whole genome scans from Japan and from the US identified a locus on chromosome 8q24 that showed evidence for linkage with AITD and HT. Recent studies have demonstrated an association between thyroglobulin (Tg) polymorphisms and AITD in Caucasians, suggesting that Tg is a susceptibility gene on 8q24.

Objectives

The objective of the study was to refine Tg association with AITD, by analyzing a panel of 25 SNPs across an extended 260 kb region of the Tg.

Methods

We studied 458 Japanese AITD patients (287 GD and 171 HT patients) and 221 matched Japanese control su

SUBMITTER: Ban Y 

PROVIDER: S-EPMC3360768 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature