AIM1 promoter hypermethylation as a predictor of decreased risk of recurrence following radical prostatectomy.

ABSTRACT:

Purpose

To evaluate the prognostic significance of six epigenetic biomarkers (AIM1, CDH1, KIF1A, MT1G, PAK3, and RBM6 promoter hypermethlation) in a homogeneous group of prostate cancer patients, following radical prostatectomy (RP).

Patients and methods

Biomarker analyses were performed retrospectively on tumors from 95 prostate cancer patients all with a Gleason score of 3 + 4 = 7 and a minimum follow-up period of 8 years. Using Quantitative Methylation Specific PCR (QMSP), we analyzed the promoter region of six genes in primary prostate tumor tissues. Time to any progression was the primary endpoint and development of metastatic disease and/or death from prostate cancer was a secondary endpoint. The association of clinicopathological and biomolecular risk factors to recur

SUBMITTER: Rosenbaum E 

PROVIDER: S-EPMC3360823 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature