Ontology highlight
ABSTRACT:
SUBMITTER: Swartling FJ
PROVIDER: S-EPMC3360885 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Cancer cell 20120501 5
The proto-oncogene MYCN is mis-expressed in various types of human brain tumors. To clarify how developmental and regional differences influence transformation, we transduced wild-type or mutationally stabilized murine N-myc(T58A) into neural stem cells (NSCs) from perinatal murine cerebellum, brain stem, and forebrain. Transplantation of N-myc(WT) NSCs was insufficient for tumor formation. N-myc(T58A) cerebellar and brain stem NSCs generated medulloblastoma/primitive neuroectodermal tumors, whe ...[more]