Differential regulation of proteasome function in isoproterenol-induced cardiac hypertrophy.

ABSTRACT:

Rationale

Proteasomal degradation is altered in many disease phenotypes including cardiac hypertrophy, a prevalent condition leading to heart failure. Our recent investigations identified heterogeneous subpopulations of proteasome complexes in the heart and implicated multiple mechanisms for their regulation.

Objective

The study aimed at identification of molecular mechanisms changing proteasome function in the hypertrophic heart.

Method and results

Proteasome function, expression, and assembly were analyzed during the development of cardiac hypertrophy induced by β-adrenergic stimulation. The analysis revealed, for the first time, divergent regulation of proteasome function in cardiac hypertrophy. Proteasome complexes have 3 different proteolytic activities, which ar

SUBMITTER: Drews O 

PROVIDER: S-EPMC3360925 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature