Characterization of the expression pattern of the PRC2 core subunit Suz12 during embryonic development of Xenopus laevis.

ABSTRACT: The Polycomb repressive complex 2 is a multimeric aggregate that mediates silencing of a broad range of genes, and is associated with important biological contexts such as stem cell maintenance and cancer progression. PRC2 mainly trimethylates lysine 27 of histone H3 and is composed of three essential core subunits: EZH2, EED, and SUZ12. The Xenopus orthologs of PRC2 subunits Ezh2 and Eed have been described but Suz12 remained unidentified. Here, we report the cloning of the Xenopus Suz12, and determine its spatiotemporal expression during development. Xsuz12 transcript is provided maternally and continues to be expressed throughout development, particularly in the anterior part of the developing central nervous system. Importantly, comparative analysis of the expression of the PRC2 subuni

SUBMITTER: Aldiri I 

PROVIDER: S-EPMC3360962 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature