GABA-A receptor genes do not play a role in genetics of Lesch's typology in Caucasian subjects.

ABSTRACT:

Introduction

Lesch's typology differentiates alcoholics into different treatment response subgroups. The effects of ethanol are mediated, to an important extent, via the GABA-ergic system.

Material and methods

We have evaluated the linkage disequilibrium patterns and haplotype frequencies of GABRG1 and GABRA2 genes in 133 alcoholics divided according to Lesch's typology and in 145 matched controls.

Results

Besides several relationships at a threshold of statistical significance, we found no significant differences in the haplotype distribution of these genes between alcoholics and controls.

Conclusions

Lesch's typology may not be related with the genotype of alcoholics - at least in terms of genes with an established role in the development of dependency.

SUBMITTER: Grzywacz A 

PROVIDER: S-EPMC3361050 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature