Impact of race on asthma treatment failures in the asthma clinical research network.

ABSTRACT:

Rationale

Recent studies suggest that people with asthma of different racial backgrounds may respond differently to various therapies.

Objectives

To use data from well-characterized participants in prior Asthma Clinical Research Network (ACRN) trials to determine whether racial differences affected asthma treatment failures.

Methods

We analyzed baseline phenotypes and treatment failure rates (worsening asthma resulting in systemic corticosteroid use, hospitalization, emergency department visit, prolonged decrease in peak expiratory flow, increase in albuterol use, or safety concerns) in subjects participating in 10 ACRN trials (1993-2003). Self-declared race was reported in each trial and treatment failure rates were stratified by race.

Measurements and main result

SUBMITTER: Wechsler ME 

PROVIDER: S-EPMC3361331 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature