25-Hydroxyvitamin D levels and the risk of stroke: a prospective study and meta-analysis.

ABSTRACT:

Background and purpose

Despite evidence suggesting that vitamin D deficiency may lead to elevated cardiovascular disease risk, results regarding the association of 25-hydroxyvitamin D (25[OH]D) levels with stroke risk are inconclusive. We aimed to examine this association in a prospective study in women and to summarize all existing data in a meta-analysis.

Methods

We measured 25(OH)D levels among 464 women who developed ischemic stroke and an equal number of control subjects who were free of stroke through 2006 in the Nurses' Health Study (NHS). We searched MEDLINE and EMBASE for articles published through March 2011 that prospectively evaluated 25(OH)D levels in relation to stroke.

Results

After multivariable adjustment for lifestyle and dietary covariates, lower 25

SUBMITTER: Sun Q 

PROVIDER: S-EPMC3361562 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature