Apolipoprotein E genotype predicts hematoma expansion in lobar intracerebral hemorrhage.

ABSTRACT:

Background and purpose

Hematoma volume is the most potent predictor of outcome in spontaneous intracerebral hemorrhage (ICH), and hematoma expansion after hospital presentation occurs in up to 40% of individuals. Among patients with lobar ICH, the apolipoprotein E (APOE) ε2 allele predicts larger hematoma volumes at presentation. We investigated whether the ε2 allele also identifies individuals at increased risk of hematoma expansion.

Methods

We analyzed 510 patients with primary ICH and genetic data available from an ongoing prospective cohort study. Baseline and follow-up CT scans were assessed for ICH location and volume using computer-assisted volumetric methods.

Results

Individuals with lobar ICH who possessed APOE ε2 were at increased risk for hematoma expansion

SUBMITTER: Brouwers HB 

PROVIDER: S-EPMC3361564 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature