Dual targeting strategies with bispecific antibodies.

ABSTRACT: Monoclonal antibodies are widely used for the treatment of cancer, inflammatory and infectious diseases and other disorders. Most of the marketed antibodies are monospecific and therefore capable of interacting and interfering with a single target. However, complex diseases are often multifactorial in nature, and involve redundant or synergistic action of disease mediators or upregulation of different receptors, including crosstalk between their signaling networks. Consequently, blockade of multiple, different pathological factors and pathways may result in improved therapeutic efficacy. This result can be achieved by combining different drugs, or use of the dual targeting strategies applying bispecific antibodies that have emerged as an alternative to combination therapy. This review disc

SUBMITTER: Kontermann RE 

PROVIDER: S-EPMC3361654 | biostudies-literature | 2012 Mar-Apr

REPOSITORIES: biostudies-literature