Ontology highlight
ABSTRACT:
SUBMITTER: Kumari M
PROVIDER: S-EPMC3361708 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Cell metabolism 20120501 5
Numerous studies in humans link a nonsynonymous genetic polymorphism (I148M) in adiponutrin (ADPN) to various forms of fatty liver disease and liver cirrhosis. Despite its high clinical relevance, the molecular function of ADPN and the mechanism by which I148M variant affects hepatic metabolism are unclear. Here we show that ADPN promotes cellular lipid synthesis by converting lysophosphatidic acid (LPA) into phosphatidic acid. The ADPN-catalyzed LPA acyltransferase (LPAAT) reaction is specific ...[more]