Obstructive sleep apnea does not promote esophageal reflux in fibrosing interstitial lung disease.

ABSTRACT:

Background

In patients with fibrosing interstitial lung disease (fILD), gastroesophageal reflux (GER) is highly prevalent, perhaps because of the effects of lung fibrosis on altering intrathoracic pressure, diaphragm morphology and lower esophageal sphincter (LES) function. For unclear reasons, obstructive sleep apnea (OSA) is also highly prevalent among patients with fILD. We conducted this study to test our hypothesis that, in patients with fILD, OSA would exacerbate diaphragm/LES dysfunction and increase the propensity for-and severity of - GER.

Methods

We identified patients with fILD who underwent screening polysomnogram and pH or pH/impedence probe at our center during the same week. We examined the association between OSA and GER and used logistic regression to determ

SUBMITTER: Pillai M 

PROVIDER: S-EPMC3362045 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature