Relation of IL28B gene polymorphism with biochemical and histological features in hepatitis C virus-induced liver disease.

ABSTRACT:

Background/aims

Polymorphism at the IL28B gene may modify the course of hepatitis C virus (HCV) chronic infection. Our aim was to study the influence of IL28B rs12979860 gene polymorphism on the biochemistry and pathology of HCV-induced disease in the clinical course from mild chronic hepatitis C to hepatocellular carcinoma.

Methods

We have determined the rs12979860 single nucleotide polymorphism (SNP) upstream IL28B gene in two groups of patients with HCV-induced chronic liver disease: 1) 268 patients (159 men) with biopsy-proven chronic hepatitis C, to analyse its relation with biochemical, virological and histological features; and 2) 134 patients (97 men) with HCV-related hepatocellular carcinoma. The distribution of the analysed SNP in hepatocellular carcinoma patients

SUBMITTER: Agundez JA 

PROVIDER: S-EPMC3362530 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature