Deregulation of ion channel and transporter encoding genes in pediatric gliomas.

ABSTRACT: Brain tumors, including the majority gliomas, are the leading cause of cancer-related death in children. World Health Organization has divided pediatric brain tumors into different grades and, based upon cDNA microarray data identifying gene expression profiles (GEPs), it has become evident in the last decade that the various grades involve different types of genetic alterations. However, it is not known whether ion channel and transporter genes, intimately involved in brain functioning, are associated with such GEPs. We determined the GEPs in an available cohort of 10 pediatric brain tumors initially by comparing the data obtained from four primary tumor samples and corresponding short-term cultures. The correspondence between the two types of samples was statistically significant. We the

SUBMITTER: Masselli M 

PROVIDER: S-EPMC3362739 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature