Infant outcomes after maternal antiretroviral exposure in resource-limited settings.

ABSTRACT:

Background and objective

The impact of maternal antiretrovirals (ARVs) during pregnancy, labor, and postpartum on infant outcomes is unclear.

Methods

Infants born to HIV-infected mothers in ARV studies were followed for 18 months.

Results

Between June 2006 and December 2008, 236 infants enrolled from Africa (n = 36), India (n = 47), Thailand (n = 152), and Brazil (n = 1). Exposure to ARVs in pregnancy included ≥ 3 ARVs (10%), zidovudine/intrapartum ARV (81%), and intrapartum ARV (9%). There were 4 infant infections (1 in utero, 3 late postpartum) and 4 deaths with 1.8% mortality (95% confidence interval [CI], 0.1%-3.5%) and 96.4% HIV-1-free survival (95% CI, 94.0%-98.9%). Birth weight was ≥ 2.5 kg in 86%. In the first 6 months, Indian infants (nonbreastfed) had lowest

SUBMITTER: Nielsen-Saines K 

PROVIDER: S-EPMC3362906 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature