Childhood cancer incidence trends in association with US folic acid fortification (1986-2008).

ABSTRACT:

Objective

Epidemiologic evidence indicates that prenatal vitamin supplementation reduces risk for some childhood cancers; however, a systematic evaluation of population-based childhood cancer incidence trends after fortification of enriched grain products with folic acid in the United States in 1996-1998 has not been previously reported. Here we describe temporal trends in childhood cancer incidence in association with US folic acid fortification.

Methods

Using Surveillance, Epidemiology, and End Results program data (1986-2008), we calculated incidence rate ratios and 95% confidence intervals to compare pre- and postfortification cancer incidence rates in children aged 0 to 4 years. Incidence trends were also evaluated by using joinpoint and loess regression models.

Resu

SUBMITTER: Linabery AM 

PROVIDER: S-EPMC3362910 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature