Aging Uncouples Heritability and Expression-QTL in Caenorhabditis elegans.

ABSTRACT: The number and distribution of gene expression QTL (eQTL) represent the genetic architecture of many complex traits, including common human diseases. We previously reported that the heritable eQTL patterns are highly dynamic with age in an N2 × CB4856 recombinant inbred population of the nematode Caenorhabditis elegans. In particular, we showed that the number of eQTL decreased with age. Here, we investigated the reason for this decrease by combining gene expression profiles at three ages in the wild types N2 and CB4856 with the reported expression profiles of the RIL population. We determined heritability and transgression (when gene expression levels in the RILs are more extreme than the parents) and investigated their relation with eQTL changes with age. Transgressive segregation was wi

SUBMITTER: Vinuela A 

PROVIDER: S-EPMC3362942 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature