Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC3363326 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Zhang Yonghui Y Fu-Yang Lin Li Kai K Zhu Wei W Liu Yi-Liang YL Cao Rong R Pang Ran R Lee Eunhae E Axelson Jordan J Hensler Mary M Wang Ke K Molohon Katie J KJ Wang Yang Y Mitchell Douglas A DA Nizet Victor V Oldfield Eric E
ACS medicinal chemistry letters 20120401 5
We report the discovery of antibacterial leads, keto- and diketo-acids, targeting two prenyl transferases: undecaprenyl diphosphate synthase (UPPS) and dehydrosqualene synthase (CrtM). The leads were suggested by the observation that keto- and diketo-acids bind to the active site Mg(2+)/Asp domain in HIV-1 integrase, and similar domains are present in prenyl transferases. We report the x-ray crystallographic structures of one diketo-acid and one keto-acid bound to CrtM, which supports the Mg(2+) ...[more]