The neuropeptide VGF produces antidepressant-like behavioral effects and enhances proliferation in the hippocampus.

ABSTRACT: Brain-derived neurotrophic factor (BDNF) is upregulated in the hippocampus by antidepressant treatments, and BDNF produces antidepressant-like effects in behavioral models of depression. In our previous work, we identified genes induced by BDNF and defined their specific roles in hippocampal neuronal development and plasticity. To identify genes downstream of BDNF that may play roles in psychiatric disorders, we examined a subset of BDNF-induced genes also regulated by 5-HT (serotonin), which includes the neuropeptide VGF (nonacronymic). To explore the function of VGF in depression, we first investigated the expression of the neuropeptide in animal models of depression. VGF was downregulated in the hippocampus after both the learned helplessness and forced swim test (FST) paradigms. Conver

SUBMITTER: Thakker-Varia S 

PROVIDER: S-EPMC3363962 | biostudies-literature | 2007 Nov

REPOSITORIES: biostudies-literature